The reports of fexofenadine extreme of the dose are infrequent, and because this, the results is not established well. No death was not presented in the experimentation in the rats, in 5000 mg/$l*kg, that the dose recommended greatest for a person of the adult is 110 times. The research additional does not present no death in the rats in the same concentration, that levels four one hundred times the dose recommended in a person of the adult. The research for the people oscillates of an only magnesium of dose 800, while two times the magnesium of dose 690 of the day for one month, without the consideravelmente favorable results clìnica, when placebo will be compared with one. The end to produce the part of piperidines, two teams of fajnyljke are imported initially using a reaction of grignard in ester, that it gives to an alcohol tertiary. The team of alkylopojej'taj of amines then with a protected aldehyde, the aldehyde is recouped then of deprotection with the acid one. The part of the remain of molecule is produced by one alkylopoj'isi double of carbanion of iodomethane that emanates of nitrile. The team of ydroly'etaj of nitriles then in acid carboxylic. Bromide of aryljko ' is then it produces the union of organolithium, that it can be connected with the aldehyde part that gives (after the preparation) fexofenadine.
